Dangers of Mixing Drugs and Alcohol: A Guide for At-Risk Users and Families

Dangers of mixing alcohol and drugs.
Dominic Nicosia

Written By

Dominic Nicosia
Dr. Po-Chang Hsu -

Medically Reviewed By:

Dr. Po-Chang Hsu

Last Medically Reviewed on January 22, 2024

Whether you’re going through substance use disorder yourself or you have watched a friend or family member struggle with addiction, you probably know how common it is to mix drugs and alcohol. Data from the Substance Abuse and Mental Health Services Administration’s (SAMHSA) 2019 National Survey on Drug Use and Health indicates that 11.8 percent of those who struggle with substance use disorder (SUD) battle simultaneous alcohol and drug abuse. If you or someone you care about are among these startling numbers, you need to know about the dangers of mixing drugs and alcohol and how it can significantly increase the likelihood of worsening addiction…and even fatal overdose.

Why Do People Mix Drugs and Alcohol?

There are many different behaviors that drive people to mix alcohol and illicit drugs, including but not limited to:

  • Magnifying the Experience – Sometimes people think that drinking will increase their high and magnify the euphoria they’re experiencing from drug use. They’re only partially right; drinking does increase the effects of other illicit drugs, but mainly the negative factors that can increase overdose risk. This is especially true when you mix alcohol and other central nervous system depressants.
  • Coping with Withdrawal Symptoms – There is a complex interplay between drugs, alcohol, and withdrawal from each. For example, some doctors may recommend certain types of medications, like benzodiazepines and anti-seizure meds, to help people cope with severe alcohol withdrawal. These drugs should never be taken without a prescription in any context, especially when alcohol is involved. On the other side of the coin, people may drink to dull the pain and other effects of opioid withdrawal or to calm down while dealing with meth-related paranoia or psychosis.
  • Because “Why Not?” – For many people, mixing drugs and alcohol just “comes with the territory”. Maybe they’re at a party and decide to chase their acid with beer; maybe they’re home alone and decide to “make a night of it” with some cocaine and vodka; sometimes people just figure: “Well…in for a penny in for a pound! I might as well!”. You may drink and use drugs at the same time because “it’s there”. If you’re already engaging in prolonged and untreated drug abuse, it’s highly unlikely that you’ll draw the line at drinking.
  • “Did I REALLY Drink That Much?”– You may not even realize how much you’re drinking at the moment because you’re so high on something else. In the context of social drug use, it’s not uncommon to keep downing drinks without being able to keep track of how much or even what type of alcohol you’ve consumed.

This level of impaired judgment can be more dangerous than you or your loved one may realize. Data from the Centers for Disease Control and Prevention indicates that overdose deaths involving polysubstance abuse are on the rise, partially because victims are unaware that they’re taking a certain drug. This lack of awareness can stem from dealer deception or lack of control due to intoxication. The dangers of mixing drugs and alcohol vary, depending on what substances you’re using.

Dangers of Mixing Alcohol with Benzos

One of the most common and deadly forms of co-occurring drug and alcohol abuse is mixing alcohol with benzodiazepines (benzos). As previously stated, doctors often prescribe benzos like Valium® or Librium® for serious alcohol withdrawal symptoms, like seizures. Unfortunately, however, even with the use of these drugs, it’s possible to experience relapse.

Both alcohol and benzos are central nervous system (CNS) depressants, otherwise known as downers. They both work by regulating the neurotransmitter gamma-aminobutyric acid (GABA) to help reduce stress and promote calmness. Unfortunately, this process includes slowing down your breathing and heart rate, which means that you’re taking two substances that decelerate your heartbeat and respiratory function at the same time. Many who succumb to benzodiazepine overdose have alcohol in their systems at the time of their death.

Dangers of Mixing Alcohol and Opioids

Data from the Pew Research Center indicates that 15 percent of opioid fatalities involved alcohol in 2017. With the rise in drinking, as well as opioid deaths, amid the COVID-19 pandemic, this number has likely only gotten larger. They also report that around 23 percent of people with an opioid use disorder have a concurrent alcohol use disorder.

Like benzos, opioids like oxycodone and hydrocodone work by depressing the CNS, in this case, blocking the perception of pain in the brain. Both alcohol and opioids lower blood pressure, slow reflexes and decelerate breathing, which means compounded use of each substance can be, and often is, deadly. Opioids are not meant to be a long-term solution to pain, and it’s best to refrain from drinking while on a prescription for narcotic painkillers. Talk to your doctor about any concerns you have with any side effects of opioids you are experiencing.

Dangers of Mixing Alcohol with Heroin

The risks of mixing alcohol with heroin mirror those of simultaneous drinking and opioid use, slowing down respiratory function and heart rate to the point of unconsciousness and possible fatality. What is, perhaps, even more alarming than any other type of drug association is that those who abuse alcohol are twice as likely to develop heroin addiction at some point in their lives, according to data from the Centers for Disease Control and Prevention. The agency also reports that heroin users are 15 times more likely to use cocaine and 40 times more likely to have used prescription painkillers.

Dangers of Mixing Alcohol with Cocaine

Mixing cocaine and alcohol is alarmingly common at parties and in social contexts, particularly among young adults. The CDC reports that cocaine is involved in nearly 23 percent of all overdose deaths in 2021, and many who overdose from cocaine have alcohol as a co-occurring risk factor. Mixing cocaine and alcohol produces a separate chemical called cocaethylene, which can increase the risk of toxicity to the heart and other major organs. Prolonged and untreated simultaneous cocaine and alcohol use can lead to a variety of other serious health effects, including, but not limited to:

  • Stroke
  • Blood Clots
  • Brain Bleeding
  • Heart Attack
  • Paranoia
  • Seizures and Convulsions
  • Aggressive and Violent Behavior
  • Coma and Sudden Death
  • Elevated Body Temperature
  • Increased Risk of Cancer

Simultaneous cocaine and alcohol use also increases the likelihood of ER visits and emergency hospital admission.

Getting Treatment for Combined Alcohol and Drug Use  

In order to manage the complicated and interconnected physical and behavioral effects of co-occurring alcohol and drug use, you or your loved one should seek comprehensive medical and behavioral care. Treatment for alcohol and/or drug addiction should include medically supervised detox and withdrawal management to address the complex long-term medical issues associated with protracted drinking and drug use, as well as compassionate and supportive behavioral rehab for the psychological origins and triggers of substance abuse. Simultaneous drug and alcohol abuse requires targeted and in-depth management of each associated condition for comprehensive healing and should be tailored to your individual care needs.

Overcome Alcohol and Drug Addiction Starting Right Now

It may seem impossible to envision your life without drugs and alcohol to help you feel “normal”, but there is nothing normal about an endless cycle of pain, sickness, and dysfunction from withdrawal and relapse; nor is there anything normal about the legal issues, relationship damage, disease risk, and financial destruction often linked to drinking and drug use. When you mix alcohol and other drugs, you compound the immediate and long-term dangers of substance use and increase your potential risk of overdose fatality.

Recovery Unplugged is ready to help you or your loved one reclaim your health, dignity, and quality of life from drinking and drug addiction. We accept most major insurance plans and offer all levels of care, including medical detox and inpatient rehab. Contact us today to get help at one of our locations nationwide. We’re waiting to guide you toward recovery and a better future.

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Dominic Nicosia

Dominic, a seasoned content writer at Recovery Unplugged, brings a wealth of knowledge and expertise to the realm of healthcare writing, particularly in the addiction and recovery field.

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