How Long Does Fentanyl Stay in Urine?

How Long Does Fentanyl Stay in Urine?
Amanda Stevens

Written By

Amanda Stevens
Dr. Po-Chang Hsu -

Medically Reviewed By:

Dr. Po-Chang Hsu

Last Medically Reviewed on February 22, 2024

  • The detection time of fentanyl in urine can be influenced by factors such as individual metabolism, kidney function, the amount of drug taken, frequency of use, and the sensitivity of the testing method.
  • Typically fentanyl can be detected for up to three days since the last dose.
  • aking other medications may not significantly impact the detection time of fentanyl in urine, but it can affect the overall metabolism and excretion of drugs.
  • Frequent use of the drug will also affect how long the drug stays in the system.

With the rising prevalence of fentanyl in today’s opioid crisis, it’s essential to understand the drug’s properties and how it affects our bodies. One crucial factor to consider is how long fentanyl stays in our systems.

One crucial factor to consider is the duration of fentanyl’s detectability in various biological matrices, such as urine, blood, and saliva, as this can vary.

How Long Does Fentanyl Stay in Urine?

How Long Does Fentanyl Stay in Urine?

Fentanyl is a powerful synthetic opioid[1] used to treat severe pain, especially in surgery patients.

Fentanyl has a short half-life compared to other opioids. It is metabolized quickly in the liver and eliminated from the body through urine. The detection window for fentanyl in urine depends on several factors, such as the dosage, frequency of use, and individual metabolism.

In general, fentanyl can be detected in urine for up to three days after the last dose.

However, for chronic users, the detection window in urine might occasionally extend beyond the typical three-day period. This is because fentanyl accumulates in the body over time and can take longer to be eliminated. In addition, heavy users may also experience withdrawal symptoms during this time, making it difficult to quit using the drug.

Other factors influencing detection times include age, gender, and overall health. For example, older individuals and those with liver or kidney problems may take longer to eliminate fentanyl from their systems.

It’s essential to note that urine tests typically detect the presence of fentanyl’s metabolites rather than the drug itself. After ingestion, fentanyl is broken down into norfentanyl, hydroxy, and other metabolites. These metabolites have longer half-lives and can still be detected in the urine even after the drug has been eliminated.

What Affects Fentanyl Detection Time in Urine?

Fentanyl can be detected in urine, with the detection time depending on several factors[2].


How fast fentanyl shows up in urine depends on a person’s metabolism. Those with a fast metabolism will process the drug quicker than those with a slow metabolism.

The liver is in charge of breaking down the drug, and genetic factors can influence the speed of this process. Conversely, liver damage or problems can slow down fentanyl metabolism.


As with most drugs, age can affect fentanyl detection time in urine. Older individuals tend to metabolize drugs more slowly, meaning that fentanyl will stay in their system for longer. This is because the liver becomes less efficient at metabolizing drugs as it ages.

Body Mass and Hydration

The detection time of fentanyl in urine is affected by body mass and hydration. Higher body mass results in slower drug metabolism, leading to longer detection time.

Drinking enough water can help eliminate the drug from the system faster, while dehydration prolongs detection time as the body struggles to metabolize and excrete the drug in urine.

Fentanyl Dosage and Frequency of Use

The more fentanyl a person takes, and the more frequently they use it, the longer it will take to detect it in their urine. Larger doses will take longer to eliminate from the body than smaller doses.

Additionally, frequent use of the drug will increase the detection time. Accumulating fentanyl and its breakdown products in the body due to chronic use can lead to even longer detection times.

Drug Interactions

Taking other medications can impact fentanyl detection time in urine. Certain drugs, like antidepressants and antifungal medications, can slow down fentanyl metabolism and extend its detection period.

This means that individuals taking these drugs may show positive fentanyl results on a drug test for longer. It’s essential to inform medical professionals of all medications being taken to ensure accurate drug screenings.

Additionally, the pH level of urine can also affect the detection time. Urine that is too acidic or alkaline can affect the detection time of drugs, including fentanyl. Being sick or having a urinary tract infection can also impact the pH level of urine and affect the detection time.

Types of Drug Tests For Detecting Fentanyl

Detecting fentanyl in users is important for various reasons, including checking for drug abuse or assessing intoxication levels. Several types of tests are used to detect the presence of fentanyl and its metabolites.

Standard Urine Drug Tests

Standard urine drug tests are commonly used for drug screening but may not be the most effective for detecting fentanyl specifically. Specialized fentanyl-specific immunoassay tests are often required due to fentanyl’s potency and chemical structure.

It is also worth noting that standard urine drug tests do not pick up small amounts of the drug many users consume, so they may not produce a positive result. Therefore, it is only used as an initial screening tool, and further testing is often needed for confirmation.

Immunoassay Tests

Immunoassay tests, while commonly used for initial drug screening, may not be highly sensitive to fentanyl specifically without specialized modifications or tests designed for fentanyl detection.

Although these tests are rapid, they can still produce false-positive results due to other substances with similar metabolites. As with the standard urine test, if a positive result is found, further testing will be necessary to confirm fentanyl’s presence.

Gas Chromatography-Mass Spectrometry (GC-MS)

Gas chromatography-mass spectrometry (GC-MS) is a highly accurate and reliable method for confirming the presence of fentanyl, often used as a confirmatory test following initial screenings. It is designed to detect the pure form of fentanyl and its metabolites directly, thus significantly reducing the risk of false-positive results.

GC-MS combines two analysis methods, gas chromatography, and mass spectrometry, to detect drugs in the individual’s system. GC-MS is the most accurate method available, but it is expensive and time-consuming to perform and requires significant expertise in interpreting results.

Find Out More About How Fentanyl and Other Drugs Are Metabolized By Our Bodies

To learn more about how drugs interact with the body and their detectability on screening tests, have a look at these additional resources.

What is fentanyl?

Fentanyl is a synthetic opioid that is commonly used as a pain reliever. It is a highly potent drug that can be up to 100 times stronger than morphine.[3]

How is fentanyl used?

Fentanyl can be administered through injection, transdermal patches, nasal sprays, lozenges, and pills. It is usually prescribed to patients with severe pain, such as those undergoing surgery or cancer treatment.

What are the side effects of fentanyl?

The most common side effects of fentanyl include dizziness, nausea, vomiting, constipation, confusion, and drowsiness. In more severe cases, it can also cause respiratory depression and even death.

How addictive is fentanyl?

While fentanyl has a high potential for addiction, addiction is more commonly associated with misuse or abuse rather than when taken as prescribed under medical supervision.

Is fentanyl dangerous?

Fentanyl can be dangerous if misused or abused. It is often mixed with other drugs, such as heroin or cocaine, increasing the risk of overdose and death. Therefore, it is important to use fentanyl only as prescribed and to keep it out of reach of children and others who may use it for non-medical purposes.

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[1] National Institute on Drug Abuse. (2021, June 1). Fentanyl DrugFacts | National Institute on Drug Abuse (NIDA).

[2] Huhn, A. S., Hobelmann, J. G., Oyler, G. A., & Strain, E. C. (2020). Protracted Renal Clearance of Fentanyl in Persons with Opioid Use Disorder. Drug and Alcohol Dependence, 214, 108147.

[3] CDC. (2023, September 6). Fentanyl Facts.

Amanda Stevens

Amanda is a prolific medical content writer specializing in eating disorders and addiction treatment. She graduated Magna Cum Laude from Purdue University with a B.S. in Social Work.

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